If depression medication isn't working or you've tried multiple antidepressants without relief, you may qualify for our major depressive disorder clinical trial testing an investigational approach. We're enrolling adults 18–85 across Southwest Florida.
If your current antidepressant isn't working well enough—or you've tried multiple depression medications without adequate relief—you may qualify for one of our clinical trials evaluating investigational treatment approaches for major depressive disorder. We're enrolling adults 18–85 across Naples, Fort Myers, Cape Coral, Lehigh Acres, and Bonita Springs. Our research team will assess your eligibility and explain what study participation involves.
Frequently asked questions
Can I join if I already take an antidepressant?
Some studies are for people who take an antidepressant, and others ask people to stop certain medicines first. Do not stop or change any medicine on your own. Tell the study team what you take, and they will go over it with you.
Can I join if I have bipolar disorder or psychosis?
Some studies do not include people with schizophrenia, psychosis or bipolar disorder. The study team will go over your health history with you during screening.
What if I have a history of substance or alcohol use?
Some studies have rules about substance or alcohol use. The research team will discuss your history with you during screening.
What age range does this study accept?
Adults 18 to 85 can apply. Each study has its own age range, with upper limits from 64 to 85, and some also ask how old you were when your depression first started. The study team checks this during screening.
What if I'm having thoughts of suicide?
If you are in crisis now, call or text 988 (Suicide and Crisis Lifeline) or go to the nearest emergency room. Some studies have rules about this, and the study team asks about it privately during screening.
What the clinic will ask you
Studies Enrolling Now's own pre-screening questions. You answer them when you apply — they go to the clinic only.
- Has a doctor told you that you have major depression (major depressive disorder)?YesUnsureNo
- Are you taking a prescription medicine for depression right now?UnsureYesNo
- Has a doctor ever told you that you have bipolar disorder, schizophrenia, or another psychotic disorder?NoYesUnsure
- Do you have borderline personality disorder that a doctor has diagnosed?NoUnsureYes
- In the past 6 months, has a doctor or counselor told you that you have a drug or alcohol use problem (not counting tobacco or caffeine)?YesNoUnsure
- During your current bout of depression, have 2 or more different antidepressant medicines not helped enough, even at a full dose for long enough?NoUnsureYes
- Are you currently being treated for PTSD, OCD (obsessive-compulsive disorder), or panic disorder?UnsureNoYes
- Are you pregnant, breastfeeding, or planning to get pregnant in the coming months?NoYesUnsure
- Have you ever been diagnosed with epilepsy or had a seizure (not counting a seizure from a fever as a baby)?NoUnsureYes
- In the past 6 months, have you used ketamine, esketamine (Spravato), or a psychedelic such as magic mushrooms, LSD, or MDMA?YesNoUnsure
